Detailed Information |
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| Standard Gene Set Name | XIE_DCL1-7-DCL4-2-RDR6-15_UP |
| Species | Arabidopsis thaliana |
| Brief Description | Significantly co-up-regulated in dcl1-7, dcl4-2, and rdr6-15 (Table S 1 PubmedID:16129836) |
| Full Description/Abstract | Arabidopsis thaliana contains four DICER-LIKE (DCL) genes with specialized functions in small RNA biogenesis for RNA interference-related processes. A mutant with defects in DCL4 was identified and analyzed for microRNA- and endogenous, small interfering RNA (siRNA)-related functions. The dcl4-2 mutant contained normal or near-normal levels of microRNAs (21 nt) and heterochromatin-associated siRNAs (24 nt). In contrast, this mutant lacked each of three families of 21-nt trans-acting siRNAs (ta-siRNAs) and possessed elevated levels of ta-siRNA target transcripts. The dcl4-2 mutant resembled an rna-dependent RNA polymerase 6 mutant in that both mutants lacked ta-siRNAs and displayed heterochronic defects in which vegetative phase change was accelerated. Double mutant analyses with dcl2-1, dcl3-1, and dcl4-2 alleles revealed hierarchical redundancy among DCL activities, leading to alternative processing of ta-siRNA precursors in the absence of DCL4. These Data support the concept that plants have specialized and compartmentalized DCL functions for biogenesis of distinct small RNA classes |
| External Pathway ID/Pubmed ID | 16129836 |
| Source | Literature |
| Contributor/Author | Liming Lai and Xijin Ge |
| Organization of contributer | South Dakota State University |
| External URL | http://www.pnas.org/content/102/36/12984.full.pdf+html |