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| Standard Gene Set Name | SCHEIBLE_TXR1M-MUTANT/WT-REPRESSED_DN |
| Species | Arabidopsis thaliana |
| Brief Description | Repressed expression profiles of genes that are significantly induced (arithmetic mean value >1) or repressed (arithmetic mean value <1) in txr1 mutants compared to wild type plants (TableS1 PubmedID:12897252) |
| Full Description/Abstract | Thaxtomin A is a phytotoxin produced by Streptomyces scabies and other Streptomyces species, the causative agents of common scab disease in potato and other taproot crops. at nanomolar concentrations, thaxtomin causes dramatic cell swelling, reduced seedling growth, and inhibition of cellulose synthesis in Arabidopsis. We identified a mutant of Arabidopsis, designated txr1, that exhibits increased resistance to thaxtomin as a result of a decrease in the rate of toxin uptake. The TXR1 gene was identified by map-based cloning and found to encode a novel, small protein with no apparent motifs or organelle-targeting signals. The protein, which has homologs in all fully sequenced eukaryotic genomes, is expressed in all tissues and during all developmental stages analyzed. Microarray transcript profiling of some 14,300 genes revealed two stomatin-like genes that were expressed differentially in the txr1 mutant and the wild type. We propose that TXR1 is a regulator of a transport mechanism. |
| External Pathway ID/Pubmed ID | 12897252 |
| Source | Literature |
| Contributor/Author | Liming Lai and Xijin Ge |
| Organization of contributer | South Dakota State University |
| External URL | http://www.plantcell.org/cgi/reprint/15/8/1781 |