Detailed Information |
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| Standard Gene Set Name | LISTER_MET1_DN |
| Species | Arabidopsis thaliana |
| Brief Description | Met1 downregulated (TableS9 PubmedID:18423832) |
| Full Description/Abstract | Deciphering the NA layers of epigenetic regulation that control transcription is critical to understanding how plants develop and respond to their environment. Using sequencing-by-synthesis technology we directly sequenced the cytosine methylome (methylC-seq), transcriptome (mRNA-seq), and small RNA transcriptome (smRNA-seq) to generate highly integrated epigenome maps for wild-type Arabidopsis thaliana and mutants defective in DNA methyltransferase or demethylase activity. at single-base resolution we discovered extensive, previously undetected DNA methylation, identified the context and level of methylation at each site, and observed local sequence effects upon methylation state. Deep sequencing of smRNAs revealed a direct relationship between the location of smRNAs and DNA methylation, perturbation of smRNA biogenesis upon loss of CpG DNA methylation, and a tendency for smRNAs to direct strand-specific DNA methylation in regions of RNA-DNA homology. Finally, strand-specific mRNA-seq revealed altered transcript abundance of hundreds of genes, transposons, and unannotated intergenic transcripts upon modification of the DNA methylation state |
| External Pathway ID/Pubmed ID | 18423832 |
| Source | Literature |
| Contributor/Author | Liming Lai and Xijin Ge |
| Organization of contributer | South Dakota State University |
| External URL | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WSN-4S9G216-1-G&_cdi=7051&_user=10&_coverDate=05%2F02%2F2008&_sk=%23TOC%237051%232008%23998669996%23688155%23FLA%23display%23Volume_133,_Issue_3,_Pages_379-550_(2_May_2008)%23tagged%23Volume%23first%3D133%23Issue%23first%3D3%23Date%23(2_May_2008)%23&view=c&_gw=y&wchp=dGLbVtz-zSkWz&md5=5f25c1f4de9672e38caf905928b2f79e&ie=/sdarticle.pdf |