We collected 95 maize epigenomic datasets, including ChIP-seq, DNase-seq, ATAC-seq and DNA methylation data. A Hidden Markov Model was applied to aggregate or collapse the multi-dimensional matrices into a small number of chromatin states. We identified 26 chromatin states located in 3,936,844 segments across the whole genome and different chromatin states contained different epigenetic features.
After chromatin state partition, we employed self-organization mapping (SOM) to integrate, visualize, and mine diverse epigenomic datasets, including 1,350 units that contained different chromatin signatures.
State | Preferential epigenetics marks | Preferential location |
---|---|---|
State 1 | histone acetylation,Mnase,acessible DNA | 3'UTR,promoter,intron |
State 2 | H3K4me3,H3K36me3,acessible DNA | 3'UTR,promoter,intergenic |
State 3 | H3K4me3,H3K36me3,acessible DNA | intron,repeat_region |
State 4 | histone acetylation,H3K4me3,H3K36me3,acessible DNA | promoter,5'UTR,exon,3'UTR |
State 5 | histone acetylation,H3K4me3,H3K36me3,acessible DNA | exon,intron,promoter,5'UTR,3'UTR |
State 6 | histone acetylation,H3K4me3,H3K27me3 | exon,promoter,5'UTR,3'UTR |
State 7 | histone acetylation,Mnase,H3K4me3,H3K27me3,acessible DNA | promoter,intergenic,3'UTR |
State 8 | H3K27me3,Mnase, histone acetylation | promoter,intergenic,3'UTR,repeat_region |
State 9 | H3K36me3,H3K9ac,H3K56ac | intron,exon,promoter,centromere |
State 10 | H3K27me3 | intergenic,repeat_region,promoter |
State 11 | Mnase,acessible DNA, histone acetylation,H3K9me2,CENH,DNA Methylation | intergenic,repeat_region,3'UTR,promoter |
State 12 | Mnase,ZmRAD51 | intergenic,repeat_region |
State 13 | Mnase,ZmRAD51 | intergenic,repeat_region,promoter |
State 14 | Mnase,CENH,DNA Methylation,H3K9me2,ZmRAD51 | intergenic,repeat_region,promoter |
State 15 | Mnase | intergenic,repeat_region |
State 16 | Mnase,H3K9me2,DNA Methylation | intergenic,repeat_region,promoter |
State 17 | Mnase,H3K9me2 | intergenic,repeat_region |
State 18 | DNA Methylation,H3K9me2,Mnase | intergenic,repeat_region |
State 19 | DNA Methylation,Mnase,H3K9me2 | intergenic,repeat_region |
State 20 | CENH | intergenic,repeat_region,centromere |
State 21 | CENH,Mnase,H3K9me2,DNA Methylation | intergenic,repeat_region,centromere |
State 22 | Mnase,CENH,H3K9me2,DNA Methylation | intergenic,repeat_region |
State 23 | ZmO2 | intergenic,repeat_region |
State 24 | H3K9me2,DNA Methylation,Mnase(weak signal) | intergenic,repeat_region |
State 25 | rare signal | intergenic,repeat_region |
State 26 | H3K9me2 | intergenic,repeat_region |
Segment counts of SOM map | Nucleotide counts of SOM map |