We collected 100 rice epigenomic datasets, including ChIP-seq, DNase-seq, ATAC-seq and DNA methylation data. A Hidden Markov Model was applied to aggregate or collapse the multi-dimensional matrices into a small number of chromatin states. We identified 38 chromatin states located in 831,235 segments across the whole genome and different chromatin states contained different epigenetic features.
After chromatin state partition, we employed self-organization mapping (SOM) to integrate, visualize, and mine diverse epigenomic datasets, including 1,350 units that contained different chromatin signatures.
State | Preferential epigenetics marks | Preferential location |
---|---|---|
State 1 | weak histone acetylation | intron,promoter,3'UTR,intergenic |
State 2 | H3K36me1,histone acetylation | promoter,3'UTR,intergenic |
State 3 | H3K36me2,histone acetylation | 3'UTR |
State 4 | H3K36me2,H3K36me3,H3K4me2 | exon |
State 5 | H3K36me3,H3K4me2 | intron |
State 6 | H3K27me3 | intergenic,intron,promoter |
State 7 | H3K27me3 | intergenic,intron,promoter |
State 8 | H3K27me3 | intergenic,intron,promoter |
State 9 | H3K27me3,H2A.Z | intergenic,intron,promoter |
State 10 | H3K27me3,H2A.Z,H3K9ac,H3K23ac,H3K4me3,H3K4me2 | exon |
State 11 | H3K9ac,H3K23ac,H3K4me3,H3K4me2,H3K27me3,H2A.Z | exon,promoter |
State 12 | H2A.Z,histone acetylation,H3K4me2,H3K4me3 | exon,promoter |
State 13 | histone acetylation,H3K4me3,H3K4me2,H3K36me3,H3K36me2,H2A.Z | 5'UTR |
State 14 | H3K4me3,H3K4me3,H3K36me3,H2A.Z,histone acetylation | intron |
State 15 | H3K4me3,H3K4me3,H3K36me3 | intron |
State 16 | H3K4me3,histone acetylation,H2A.Z | exon,promoter,5'UTR |
State 17 | histone acetylation,acessible DNA,H3K4me2,H3K4me3 | promoter,exon,3'UTR |
State 18 | histone acetylation,acessible DNA,H2A.Z,H3K4me3 | 5'UTR,promoter,intergenic |
State 19 | DNA methylation,H3K4me3,H4K12ac,H4K16ac,OsNF-YB1,OsbZIP | centromere,intergenic |
State 20 | accessible DNA,H2A.Z,histone acetylation,H3K27me3,DNA methylation | intergenic,promoter,intron |
State 21 | acessible DNA | intergenic,promoter |
State 22 | acessible DNA | intergenic,promoter |
State 23 | acessible DNA | intergenic,promoter |
State 24 | acessible DNA | intergenic,promoter |
State 25 | H2A.Z,H3K4me2,H3K4me3,histone acetylation | promoter,intergenic,intron,3'UTR |
State 26 | DNA methylation,OsNF-YB1 | intergenic,promoter,intron |
State 27 | H3K9me2,DNA methylation,OsNF-YB1 | intergenic,TE,promoter,exon |
State 28 | H3K9me2,DNA methylation,Mnase | TE,intergenic,intron,promoter,exon |
State 29 | DNA methylation,H3K9me2,CENH3,Mnase | TE,exon,promoter,intron,intergenic |
State 30 | H3K9me2,DNA methylation | TE,exon,intron,promoter,intergenic |
State 31 | H3K9me2,CENH3,DNA methylation | TE,intron,intergenic,exon,promoter, |
State 32 | H3K9me2,CENH3,DNA methylation,Mnase | TE,intergenic,intron,exon,promoter |
State 33 | DNA methylation,H3K9me2 | TE,exon,intergenic,promoter,intron |
State 34 | DNA methylation,H3K36,H3K4me2 | intron |
State 35 | DNA methylation,H3K27me3,H3K36me1,H3K36me2,H3K36me3 | intergenic,intron,promoter |
State 36 | DNA methylation,H3K36me1 | intergenic,promoter,intron |
State 37 | DNA methylation | intergenic,intron,promoter |
State 38 | rare signal | intergenic,promoter,intron |
Segment counts of SOM map | Nucleotide counts of SOM map |